Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.

ABSTRACT: Species of Candida, primarily C. albicans and with increasing prevalence, C. glabrata, are responsible for the majority of fungal bloodstream infections that cause morbidity, especially among immune compromised patients. While the development of new antifungal agents that target the essential enzyme, dihydrofolate reductase (DHFR), in both Candida species would be ideal, previous attempts have resulted in antifolates that exhibit inconsistencies between enzyme inhibition and antifungal properties. In this article, we describe the evaluation of pairs of propargyl-linked antifolates that possess similar physicochemical properties but different shapes. All of these compounds are effective at inhibiting the fungal enzymes and the growth of C. glabrata; however, the inhibition of the growth of

SUBMITTER: G-Dayanandan N 

PROVIDER: S-EPMC3983340 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature