The most effective gold nanorod size for plasmonic photothermal therapy: theory and in vitro experiments.

ABSTRACT: The development of new and improved photothermal contrast agents for the successful treatment of cancer (or other diseases) via plasmonic photothermal therapy (PPTT) is a crucial part of the application of nanotechnology in medicine. Gold nanorods (AuNRs) have been found to be the most effective photothermal contrast agents, both in vitro and in vivo. Therefore, determining the optimum AuNR size needed for applications in PPTT is of great interest. In the present work, we utilized theoretical calculations as well as experimental techniques in vitro to determine this optimum AuNR size by comparing plasmonic properties and the efficacy as photothermal contrast agents of three different sizes of AuNRs. Our theoretical calculations showed that the contribution of absorbance to the total extinc

SUBMITTER: Mackey MA 

PROVIDER: S-EPMC3983380 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature