A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations.

ABSTRACT:

Aims/hypothesis

Individuals with impaired fasting glucose (IFG) are at increased risk of developing diabetes over the subsequent decade. However, there is uncertainty as to the mechanisms contributing to the development of diabetes. We sought to quantitate insulin secretion and action across the prediabetic range of fasting glucose.

Methods

We studied a cohort of 173 individuals with a fasting glucose concentration <7·0 mM after an overnight fast using a 75-g oral glucose tolerance test (OGTT). Insulin action (S(i)) was estimated using the oral glucose minimal model, and β-cell responsivity indices (φ) were estimated using the oral C-peptide minimal model. The disposition index (DI) for each individual was calculated. The relationship of DI, φ and S(i) with fasting and postc

SUBMITTER: Sathananthan A 

PROVIDER: S-EPMC3983528 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature