Cell-cycle regulated transcription associates with DNA replication timing in yeast and human.

ABSTRACT:

Background

Eukaryotic DNA replication follows a specific temporal program, with some genomic regions consistently replicating earlier than others, yet what determines this program is largely unknown. Highly transcribed regions have been observed to replicate in early S-phase in all plant and animal species studied to date, but this relationship is thought to be absent from both budding yeast and fission yeast. No association between cell-cycle regulated transcription and replication timing has been reported for any species.

Results

Here I show that in budding yeast, fission yeast, and human, the genes most highly transcribed during S-phase replicate early, whereas those repressed in S-phase replicate late. Transcription during other cell-cycle phases shows either the opposit

SUBMITTER: Fraser HB 

PROVIDER: S-EPMC3983658 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature