Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.

ABSTRACT: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.

SUBMITTER: Chmielecki J 

PROVIDER: S-EPMC3984043 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature