Plasma metabolomic profiling suggests early indications for predisposition to latent insulin resistance in children conceived by ICSI.

ABSTRACT:

Background

There have been increasing indications about an epigenetically-based elevated predisposition of assisted reproductive technology (ART) offspring to insulin resistance, which can lead to an unfavorable cardio-metabolic profile in adult life. However, the relevant long-term systematic molecular studies are limited, especially for the IntraCytoplasmic Sperm Injection (ICSI) method, introduced in 1992. In this study, we carefully defined a group of 42 prepubertal ICSI and 42 naturally conceived (NC) children. We assessed differences in their metabolic profile based on biochemical measurements, while, for a subgroup, plasma metabolomic analysis was also performed, investigating any relevant insulin resistance indices.

Methods & results

Auxological and biochemical param

SUBMITTER: Gkourogianni A 

PROVIDER: S-EPMC3984097 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature