Resistance to systemic inflammation and multi organ damage after global ischemia/reperfusion in the arctic ground squirrel.

ABSTRACT:

Introduction

Cardiac arrest (CA) and hemorrhagic shock (HS) are two clinically relevant situations where the body undergoes global ischemia as blood pressure drops below the threshold necessary for adequate organ perfusion. Resistance to ischemia/reperfusion (I/R) injury is a characteristic of hibernating mammals. The present study sought to determine if arctic ground squirrels (AGS) are protected from systemic inflammation and multi organ damage after CA- or HS-induced global I/R and if, for HS, this protection is dependent upon their hibernation season.

Methods

For CA, rats and summer euthermic AGS (AGS-EU) were asphyxiated for 8 min, inducing CA. For HS, rats, AGS-EU, and winter interbout arousal AGS (AGS-IBA) were subject to HS by withdrawing blood to a mean arterial pre

SUBMITTER: Bogren LK 

PROVIDER: S-EPMC3984146 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature