Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men.

ABSTRACT:

Background

Filaggrin is an epidermal protein that is crucial for skin barrier function. Up to 10% of Europeans and 5% of Asians carry at least one null allele in the filaggrin gene (FLG). Reduced expression of filaggrin in carriers of the null allele is associated with facilitated transfer of allergens across the epidermis. We hypothesized that these individuals may have increased transdermal uptake of endocrine disruptors, including phthalates.

Objectives

We investigated urinary excretion of phthalate metabolites and testicular function in young men with and without FLG loss-of-function variants in a cross-sectional study of 861 young men from the general Danish population.

Methods

All men were genotyped for FLG R501X, 2282del4, and R2447X loss-of-function variants.

SUBMITTER: Joensen UN 

PROVIDER: S-EPMC3984221 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature