Transgenic zebrafish reveal tissue-specific differences in estrogen signaling in response to environmental water samples.

ABSTRACT:

Background

Environmental endocrine disruptors (EEDs) are exogenous chemicals that mimic endogenous hormones such as estrogens. Previous studies using a zebrafish transgenic reporter demonstrated that the EEDs bisphenol A and genistein preferentially activate estrogen receptors (ERs) in the larval heart compared with the liver. However, it was not known whether the transgenic zebrafish reporter was sensitive enough to detect estrogens from environmental samples, whether environmental estrogens would exhibit tissue-specific effects similar to those of BPA and genistein, or why some compounds preferentially target receptors in the heart.

Methods

We tested surface water samples using a transgenic zebrafish reporter with tandem estrogen response elements driving green fluorescent

SUBMITTER: Gorelick DA 

PROVIDER: S-EPMC3984228 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature