Human health effects of tetrachloroethylene: key findings and scientific issues.

ABSTRACT:

Background

The U.S. Environmental Protection Agency (EPA) completed a toxicological review of tetrachloroethylene (perchloroethylene, PCE) in February 2012 in support of the Integrated Risk Information System (IRIS).

Objectives

We reviewed key findings and scientific issues regarding the human health effects of PCE described in the U.S. EPA's Toxicological Review of Tetrachloroethylene (Perchloroethylene).

Methods

The updated assessment of PCE synthesized and characterized a substantial database of epidemiological, experimental animal, and mechanistic studies. Key scientific issues were addressed through modeling of PCE toxicokinetics, synthesis of evidence from neurological studies, and analyses of toxicokinetic, mechanistic, and other factors (tumor latency, severit

SUBMITTER: Guyton KZ 

PROVIDER: S-EPMC3984230 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature