GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study.

ABSTRACT:

Background

Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma.

Objective

Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood asthma.

Methods

Traffic-related air pollution, asthma, wheeze, gene variant, and potential confounder data were pooled across six birth cohorts. Parents reported physician-diagnosed asthma and wheeze from birth to 7-8 years of age (confirmed by pediatric allergist in two cohorts). Individual estimates of annual average air pollution [nitrogen dioxide (NO2), particulate matter ≤ 2.5 μm (PM2.5), PM2.5 absorbance, ozone] were assigned to each child's birth addr

SUBMITTER: MacIntyre EA 

PROVIDER: S-EPMC3984232 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature