Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults.

ABSTRACT:

Background

Binge drinking is responsible for over half of all alcohol-related deaths and results in significant health and economic costs to individuals and society. Knowledge of genetic aspects of this behavior, particularly as it emerges in young adulthood, could lead to improved treatment and prevention programs.

Methods

We have focused on the association of variation in neuronal nicotinic receptor subunit genes (CHRNs) in a cohort of 702 Hispanic and non-Hispanic White young adults who are part of the Social and Emotional Contexts of Adolescent Smoking Patterns (SECASP) study. Fifty-five single nucleotide polymorphisms (SNPs) covering the variation in 5 CHRNs (CHRNA4, CHRNB2, CHRNA2, CHRNB3A6, and CHRNA5A3B4) were studied.

Results

Frequency of binge drinking and o

SUBMITTER: Coon H 

PROVIDER: S-EPMC3984345 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature