Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample.

ABSTRACT:

Background

While twin and adoption studies point to substantial genetic influence upon alcohol use, dependence, and other alcohol-related phenotypes, few of the genes underlying variation in these phenotypes have been identified. Markers in genes related to GABAergic activity-a system integral to many of alcohol's biological effects-have been implicated in alcohol use and alcohol-related psychopathology in linkage and association studies.

Methods

Using multiple methods, we conducted a comprehensive examination of the effects of markers in γ-aminobutyric acid (GABA) system genes in a community-based sample of 7,224 individuals assessed in early and middle adulthood. In addition to testing the effect of individual single nucleotide polymorphism (SNP) markers on alcohol-related

SUBMITTER: Irons DE 

PROVIDER: S-EPMC3984361 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature