Diagnostic discontinuity in psychosis: a combined study of cortical gyrification and functional connectivity.

ABSTRACT: The point of rarity in brain structure and function that separates the 2 major psychotic disorders--schizophrenia and bipolar disorder--is presently unknown. The aim of this study is to combine surface anatomical and functional imaging modalities to quantify the integrity of cortical connectivity in pursuit of the neural basis of the Kraepelinian "line of divide." We tested the hypothesis that multimodal brain regions show overlapping abnormalities in both disorders, while schizophrenia-specific defects are likely to be localized to sensory processing regions. Cortical folding patterns (gyrification) and functional connectivity hub architecture (degree centrality) were studied in a sample of 39 subjects with established schizophrenia, 20 subjects with psychotic bipolar disorder, and 34 hea

SUBMITTER: Palaniyappan L 

PROVIDER: S-EPMC3984507 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature