Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction.

ABSTRACT:

Objectives

This study sought to determine the frequency of left ventricular amyloid in heart failure with preserved ejection fraction (HFpEF).

Background

Left ventricular amyloid deposition can cause diastolic dysfunction and HFpEF.

Methods

Autopsy of left ventricular specimens from patients with antemortem diagnosis of HFpEF without clinically apparent amyloid (n = 109) and from control subjects (n = 131) were screened with sulfated Alcian blue and subsequent Congo red staining with microdissection for mass spectrometry-based proteomics to determine amyloid type. Fibrosis was assessed with quantitative whole-field digital microscopy.

Results

The presence of wild-type transthyretin (wtTTR) amyloid was associated with age at death and male sex, but the age- and

SUBMITTER: Mohammed SF 

PROVIDER: S-EPMC3984539 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature