Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression.

ABSTRACT:

Background

The aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs).

Methods

The MRI characteristics of 50 AO patients enrolled in the French national network for high-grade oligodendroglial tumors were analyzed. The genomic profiles and IDH mutational statuses were assessed using high-resolution single-nucleotide polymorphism arrays and direct sequencing, respectively. The gene expression profiles of 25 1p/19q-codeleted AOs were studied on Affymetrix expression arrays.

Results

Most of the cases were frontal lobe contrast-enhanced tumors (52%), but the radiological presentations of these cases were heterogeneous, ranging from low-grade glioma-like aspects (26%) to glioblastoma-like aspects (22%). The 1p/1

SUBMITTER: Reyes-Botero G 

PROVIDER: S-EPMC3984545 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature