Proposal for a new risk stratification classification for meningioma based on patient age, WHO tumor grade, size, localization, and karyotype.

ABSTRACT:

Background

Tumor recurrence remains the major clinical complication of meningiomas, the majority of recurrences occurring among WHO grade I/benign tumors. In the present study, we propose a new scoring system for the prognostic stratification of meningioma patients based on analysis of a large series of meningiomas followed for a median of >5 years.

Methods

Tumor cytogenetics were systematically investigated by interphase fluorescence in situ hybridization in 302 meningioma samples, and the proposed classification was further validated in an independent series of cases (n = 132) analyzed by high-density (500K) single-nucleotide polymorphism (SNP) arrays.

Results

Overall, we found an adverse impact on patient relapse-free survival (RFS) for males, presence of brain ede

SUBMITTER: Domingues PH 

PROVIDER: S-EPMC3984558 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature