Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.

ABSTRACT:

Aims

Studies have shown association between common variants in the α6-β3 nicotinic receptor subunit gene cluster and nicotine dependence in European ancestry populations. We investigate whether this generalizes to African Americans, whether the association is specific to nicotine dependence and whether this region contains additional genetic contributors to nicotine dependence.

Design

We examined consistency of association across studies and race between the α6β3 nicotinic receptor subunit locus and nicotine, alcohol, marijuana and cocaine dependence in three independent studies.

Setting

United States of America.

Participants

European Americans and African Americans from three case-control studies of substance dependence.

Measurements

Subjects were evalu

SUBMITTER: Culverhouse RC 

PROVIDER: S-EPMC3984604 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature