Developmental stage-specific regulation of the circadian clock by temperature in zebrafish.

ABSTRACT: The circadian clock enables animals to adapt their physiology and behaviour in anticipation of the day-night cycle. Light and temperature represent two key environmental timing cues (zeitgebers) able to reset this mechanism and so maintain its synchronization with the environmental cycle. One key challenge is to unravel how the regulation of the clock by zeitgebers matures during early development. The zebrafish is an ideal model for studying circadian clock ontogeny since the process of development occurs ex utero in an optically transparent chorion and many tools are available for genetic analysis. However, the role played by temperature in regulating the clock during zebrafish development is poorly understood. Here, we have established a clock-regulated luciferase reporter transgenic ze

SUBMITTER: Lahiri K 

PROVIDER: S-EPMC3984786 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature