Global analysis of miRNA gene clusters and gene families reveals dynamic and coordinated expression.

ABSTRACT: To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and clustered and homologous miRNAs may have close relationships with overlapped miRNA species. Members in the miRNA group always had various expression levels, and even some showed larger expression divergence. Despite the dynamic expression as well as individual difference, these miRNAs always indicated consistent or similar deregulation patterns. The consistent deregulation expression may contribute to dynamic and coordinated interaction between different miRNAs in regulatory n

SUBMITTER: Guo L 

PROVIDER: S-EPMC3984827 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature