Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial.

ABSTRACT:

Importance

Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.

Objective

To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA.

Design, setting, and patients

A 2-year randomized, placebo-controlled, double-blind, clinical trial involving 146 participants with symptomatic knee OA (mean age, 62.4 years [SD, 8.5]; 57 women [61%], 115 white race [79%]). Patients were enrolled at Tufts Medical Center in Boston between March 2006 and June 2009.

Intervention

Participants were randomized to receive either placebo or oral cholecalciferol, 2000 IU/d, wit

SUBMITTER: McAlindon T 

PROVIDER: S-EPMC3984919 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature