Ontology highlight
ABSTRACT:
SUBMITTER: Richard C
PROVIDER: S-EPMC3984929 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Developmental cell 20130301 6
Hematopoietic stem cells (HSCs) are produced by a small cohort of hemogenic endothelial cells (ECs) during development through the formation of intra-aortic hematopoietic cell (HC) clusters. The Runx1 transcription factor plays a key role in the EC-to-HC and -HSC transition. We show that Runx1 expression in hemogenic ECs and the subsequent initiation of HC formation are tightly controlled by the subaortic mesenchyme, although the mesenchyme is not a source of HCs. Runx1 and Notch signaling are i ...[more]