Structural fold and binding sites of the human Na⁺-phosphate cotransporter NaPi-II.

ABSTRACT: Phosphate plays essential biological roles and its plasma level in humans requires tight control to avoid bone loss (insufficiency) or vascular calcification (excess). Intestinal absorption and renal reabsorption of phosphate are mediated by members of the SLC34 family of sodium-coupled transporters (NaPi-IIa,b,c) whose membrane expression is regulated by various hormones, circulating proteins, and phosphate itself. Consequently, NaPi-II proteins are also potentially important pharmaceutical targets for controlling phosphate levels. Their crucial role in Pi homeostasis is underscored by pathologies resulting from naturally occurring SLC34 mutations and SLC34 knockout animals. SLC34 isoforms have been extensively studied with respect to transport mechanism and structure-function relationshi

SUBMITTER: Fenollar-Ferrer C 

PROVIDER: S-EPMC3984976 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature