FTO genotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial.

ABSTRACT:

Background

A common obesity-risk variant rs9939609 in the fat mass- and obesity-associated (FTO) gene was recently shown to affect appetite, and the gene is sensitive to the regulation of amino acids.

Objective

We examined the interaction between FTO genotype and protein intake on the long-term changes in appetite in a randomized controlled trial.

Design

We genotyped FTO rs9939609 in 737 overweight adults in the 2-y Preventing Overweight Using Novel Dietary Strategies trial and assessed 4 appetite-related traits including cravings, fullness, hunger, and prospective consumption.

Results

We showed that dietary protein significantly modified genetic effects on changes in food cravings and appetite scores at 6 mo after adjustment for age, sex, ethnicity, baseline b

SUBMITTER: Huang T 

PROVIDER: S-EPMC3985215 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature