Autologous transplantation as consolidation for aggressive non-Hodgkin's lymphoma.

ABSTRACT:

Background

The efficacy of autologous stem-cell transplantation during the first remission in patients with diffuse, aggressive non-Hodgkin's lymphoma classified as high-intermediate risk or high risk on the International Prognostic Index remains controversial and is untested in the rituximab era.

Methods

We treated 397 patients who had disease with an age-adjusted classification of high risk or high-intermediate risk with five cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP plus rituximab. Patients with a response were randomly assigned to receive three additional cycles of induction chemotherapy (control group) or one additional cycle of induction chemotherapy followed by autologous stem-cell transplantation (transplantation group). The

SUBMITTER: Stiff PJ 

PROVIDER: S-EPMC3985418 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature