Antisomnogenic cytokines, quality of life, and chronic rhinosinusitis: a pilot study.

ABSTRACT:

Objectives/hypothesis

Sleep disturbance, reduced quality of life (QOL), and other components of "sickness behavior" in patients with chronic rhinosinusitis (CRS) are poorly understood. These complex changes in central behavior are due to the effects of immune mediators acting in the brain. We hypothesized that immune mediators that have been associated with CRS are also associated with sickness behavior, somnifacient complaints, and CRS disease-specific QOL.

Study design

Pilot study.

Methods

Twenty patients with CRS were prospectively enrolled and completed the Pittsburgh Sleep Quality Index (PSQI), disease-specific QOL, and olfactory instruments. Ethmoid mucosa was obtained and reverse transcription-polymerase chain reaction was performed for the cytokines interleuki

SUBMITTER: Alt JA 

PROVIDER: S-EPMC3985572 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature