Diverse viral glycoproteins as well as CD4 co-package into the same human immunodeficiency virus (HIV-1) particles.

ABSTRACT:

Background

Retroviruses can acquire not only their own glycoproteins as they bud from the cellular membrane, but also some cellular and foreign viral glycoproteins. Many of these non-native glycoproteins are actively recruited to budding virions, particularly other viral glycoproteins. This observation suggests that there may be a conserved mechanism underlying the recruitment of glycoproteins into viruses. If a conserved mechanism is used, diverse glycoproteins should localize to a single budding retroviral particle. On the other hand, if viral glycoproteins have divergent mechanisms for recruitment, the different glycoproteins could segregate into different particles.

Results

To determine if co-packaging occurs among different glycoproteins, we designed an assay that combi

SUBMITTER: Gregory DA 

PROVIDER: S-EPMC3985584 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature