Ontology highlight
ABSTRACT:
SUBMITTER: Rohle D
PROVIDER: S-EPMC3985613 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130404 6132
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One potential drug target is isocitrate dehydrogenase 1 (IDH1), which is mutated in multiple human cancers. Here, we examine the role of mutant IDH1 in fully transformed cells with endogenous IDH1 mutations. A selective R132H-IDH1 inhibitor (AGI-5198) identified through a high-throughput screen blocked, in a dose-dependent manner, the ability of t ...[more]