Controlled nucleation and growth of DNA tile arrays within prescribed DNA origami frames and their dynamics.

ABSTRACT: Controlled nucleation of nanoscale building blocks by geometrically defined seeds implanted in DNA nanoscaffolds represents a unique strategy to study and understand the dynamic processes of molecular self-assembly. Here we utilize a two-dimensional DNA origami frame with a hollow interior and selectively positioned DNA hybridization seeds to control the self-assembly of DNA tile building blocks, where the small DNA tiles are directed to fill the interior of the frame through prescribed sticky end interactions. This design facilitates the construction of DNA origami/array hybrids that adopt the overall shape and dimensions of the origami frame, forming a 2D array in the core consisting of a large number of simple repeating DNA tiles. The formation of the origami/array hybrid was characteri

SUBMITTER: Li W 

PROVIDER: S-EPMC3985955 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature