The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905.

ABSTRACT:

Objective

To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk, as well as the association of microRNA (miRNA) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials.

Methods/materials

The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls. miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics, and

SUBMITTER: Lee LJ 

PROVIDER: S-EPMC3986055 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature