Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease.

ABSTRACT: The behavior and genetics of serous epithelial ovarian cancer (EOC) metastasis, the form of the disease lethal to patients, is poorly understood. The unique properties of metastases are critical to understand to improve treatments of the disease that remains in patients after debulking surgery. We sought to identify the genetic and phenotypic landscape of metastatic progression of EOC to understand how metastases compare to primary tumors. DNA copy number and mRNA expression differences between matched primary human tumors and omental metastases, collected at the same time during debulking surgery before chemotherapy, were measured using microarrays. qPCR and immunohistochemistry validated findings. Pathway analysis of mRNA expression revealed metastatic cancer cells are more proliferative

SUBMITTER: Brodsky AS 

PROVIDER: S-EPMC3986100 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature