Group-based trajectory modeling to assess adherence to biologics among patients with psoriasis.

ABSTRACT:

Background

Proportion of days covered (PDC), a commonly used adherence metric, does not provide information about the longitudinal course of adherence to treatment over time. Group-based trajectory model (GBTM) is an alternative method that overcomes this limitation.

Methods

The statistical principles of GBTM and PDC were applied to assess adherence during a 12-month follow-up in psoriasis patients starting treatment with a biologic. The optimal GBTM model was determined on the basis of the balance between each model's Bayesian information criterion and the percentage of patients in the smallest group in each model. Variables potentially predictive of adherence were evaluated.

Results

In all, 3,249 patients were included in the analysis. Four GBTM adherence groups wer

SUBMITTER: Li Y 

PROVIDER: S-EPMC3986333 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature