Apocrine secretion in Drosophila salivary glands: subcellular origin, dynamics, and identification of secretory proteins.

ABSTRACT: In contrast to the well defined mechanism of merocrine exocytosis, the mechanism of apocrine secretion, which was first described over 180 years ago, remains relatively uncharacterized. We identified apocrine secretory activity in the late prepupal salivary glands of Drosophila melanogaster just prior to the execution of programmed cell death (PCD). The excellent genetic tools available in Drosophila provide an opportunity to dissect for the first time the molecular and mechanistic aspects of this process. A prerequisite for such an analysis is to have pivotal immunohistochemical, ultrastructural, biochemical and proteomic data that fully characterize the process. Here we present data showing that the Drosophila salivary glands release all kinds of cellular proteins by an apocrine mechanis

SUBMITTER: Farkas R 

PROVIDER: S-EPMC3986406 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature