Simiate is an Actin binding protein involved in filopodia dynamics and arborization of neurons.

ABSTRACT: The Actin cytoskeleton constitutes the functional base for a multitude of cellular processes extending from motility and migration to cell mechanics and morphogenesis. The latter is particularly important to neuronal cells since the accurate functioning of the brain crucially depends on the correct arborization of neurons, a process that requires the formation of several dozens to hundreds of dendritic branches. Recently, a model was proposed where different transcription factors are detailed to distinct facets and phases of dendritogenesis and exert their function by acting on the Actin cytoskeleton, however, the proteins involved as well as the underlying molecular mechanisms are largely unknown. Here, we demonstrate that Simiate, a protein previously indicated to activate transcription,

SUBMITTER: Derlig K 

PROVIDER: S-EPMC3986562 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature