A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample.

ABSTRACT:

Background

Migraine is a common neurovascular disorder with symptoms including headache of moderate to severe intensity and recurring attacks. There is no cure for migraine today and the pathology is poorly understood. Common forms of migraine have a complex genetic background and heritability has been estimated to be around 50%. Recent genome-wide association studies (GWAS) on European and American migraine cohorts have led to the identification of new genetic risk factors for migraine.

Methods

We performed an association study in a Swedish population based cohort, investigating the frequency of eight single nucleotide polymorphisms (SNPs) recently identified as genetic risk factors for migraine in three GWAS, using available array data (Illumina Omni Express chip). The eig

SUBMITTER: Ran C 

PROVIDER: S-EPMC3986694 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature