Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium.

ABSTRACT:

Purpose

Prediction models for age-related macular degeneration (AMD) based on case-control studies have a tendency to overestimate risks. The aim of this study is to develop a prediction model for late AMD based on data from population-based studies.

Design

Three population-based studies: the Rotterdam Study (RS), the Beaver Dam Eye Study (BDES), and the Blue Mountains Eye Study (BMES) from the Three Continent AMD Consortium (3CC).

Participants

People (n = 10,106) with gradable fundus photographs, genotype data, and follow-up data without late AMD at baseline.

Methods

Features of AMD were graded on fundus photographs using the 3CC AMD severity scale. Associations with known genetic and environmental AMD risk factors were tested using Cox proportional hazard ana

SUBMITTER: Buitendijk GHS 

PROVIDER: S-EPMC3986722 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature