Relevance of the two-component sensor protein CiaH to acid and oxidative stress responses in Streptococcus pyogenes.

ABSTRACT:

Background

The production of virulence proteins depends on environmental factors, and two-component regulatory systems are involved in sensing these factors. We previously established knockout strains in all suspected two-component regulatory sensor proteins of the emm1 clinical strain of S. pyogenes and examined their relevance to acid stimuli in a natural atmosphere. In the present study, their relevance to acid stimuli was re-examined in an atmosphere containing 5% CO2.

Results

The spy1236 (which is identical to ciaHpy) sensor knockout strain showed significant growth reduction compared with the parental strain in broth at pH 6.0, suggesting that the Spy1236 (CiaHpy) two-component sensor protein is involved in acid response of S. pyogenes. CiaH is also conserved in Strept

SUBMITTER: Tatsuno I 

PROVIDER: S-EPMC3986815 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature