Classical dynamin DNM1 and DNM3 genes attain maximum expression in the normal human central nervous system.

ABSTRACT: Dynamin is a super-family of large GTPase proteins that polymerise during their biological activity. Dynamin polymers form around lipid tubes and contribute to the membrane fission and scission of nascent vesicles from parent membranes. Here we used the NCBI Gene Expression Omnibus (GEO) database and the BioGPS gene expression portal to study differential dynamin gene expression in normal human organs or tissues. From the GDS1096 and GDS596 dataset, we downloaded the relative expression levels of dynamin-related genes (presented as percentages), with respect to all of the other genes on the array (platform Affymetrix GPL96), which includes the best characterised human genes. The expression profiles of dynamin in the central nervous system (CNS) are clearly distinct from the expression prof

SUBMITTER: Romeu A 

PROVIDER: S-EPMC3986822 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature