Cannabis withdrawal in chronic, frequent cannabis smokers during sustained abstinence within a closed residential environment.

ABSTRACT:

Objectives

Chronic, frequent cannabis smokers may experience residual and offset effects, withdrawal, and craving when abstaining from the drug. We characterized the prevalence, duration, and intensity of these effects in chronic frequent cannabis smokers during abstinence on a closed research unit.

Methods

Non-treatment-seeking participants (N = 29 on admission, 66% and 34% remaining after 2 and 4 weeks) provided subjective effects data. A battery of five instruments was computer-administered daily to measure psychological, sensory, and physical symptoms associated with cannabinoid intoxication and withdrawal. Plasma and oral fluid specimens were concurrently collected and analyzed for cannabinoids. Outcome variables were evaluated as change from admission (Day 0) with regr

SUBMITTER: Lee D 

PROVIDER: S-EPMC3986824 | biostudies-literature | 2014 May-Jun

REPOSITORIES: biostudies-literature