Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines.

ABSTRACT:

Background

Deciphering the most common modes by which chromatin regulates transcription, and how this is related to cellular status and processes is an important task for improving our understanding of human cellular biology. The FANTOM5 and ENCODE projects represent two independent large scale efforts to map regulatory and transcriptional features to the human genome. Here we investigate chromatin features around a comprehensive set of transcription start sites in four cell lines by integrating data from these two projects.

Results

Transcription start sites can be distinguished by chromatin states defined by specific combinations of both chromatin mark enrichment and the profile shapes of these chromatin marks. The observed patterns can be associated with cellular functions

SUBMITTER: Rye M 

PROVIDER: S-EPMC3986914 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature