Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series.

ABSTRACT:

Background

Invasive fungal infections are very severe infections associated with high mortality rates, despite the availability of new classes of antifungal agents. Based on pathophysiological mechanisms and limited pre-clinical and clinical data, adjunctive immune-stimulatory therapy with interferon-gamma (IFN-γ) may represent a promising candidate to improve outcome of invasive fungal infections by enhancing host defence mechanisms.

Methods

In this open-label, prospective case series, we describe eight patients with invasive Candida and/or Aspergillus infections who were treated with recombinant IFN-γ (rIFN-γ, 100 μg s.c., thrice a week) for 2 weeks in addition to standard antifungal therapy.

Results

Recombinant IFN-γ treatment in patients with invasive Candida and/

SUBMITTER: Delsing CE 

PROVIDER: S-EPMC3987054 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature