Hedgehog and Wnt coordinate signaling in myogenic progenitors and regulate limb regeneration.

ABSTRACT: Amphibians have a remarkable capacity for limb regeneration. Following a severe injury, there is complete regeneration with restoration of the patterning and cellular architecture of the amputated limb. While studies have focused on the structural anatomical changes during amphibian limb regeneration, the signaling mechanisms that govern cellular dedifferentiation and blastemal progenitors are unknown. Here, we demonstrate the temporal and spatial requirement for hedgehog (Hh) signaling and its hierarchical correlation with respect to Wnt signaling during newt limb regeneration. While the dedifferentiation process of mature lineages does not depend on Hh signaling, the proliferation and the migration of the dedifferentiated cells are dependent on Hh signaling. Temporally controlled chemica

SUBMITTER: Singh BN 

PROVIDER: S-EPMC3987681 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature