Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver.

ABSTRACT:

Background

The circadian clock is a critical regulator of biological functions controlling behavioral, physiological and biochemical processes. Because the liver is the primary regulator of metabolites within the mammalian body and the disruption of circadian rhythms in liver is associated with severe illness, circadian regulators would play a strong role in maintaining liver function. However, the regulatory structure that governs circadian dynamics within the liver at a transcriptional level remains unknown. To explore this aspect, we analyzed hepatic transcriptional dynamics in Sprague-Dawley rats over a period of 24 hours to assess the genome-wide responses.

Results

Using an unsupervised consensus clustering method, we identified four major gene expression clusters, corr

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC3987685 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature