Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.

ABSTRACT:

Objective

To determine whether responsivity of reward circuitry to food predicts future increases in body mass and whether polymorphisms in DRD2 and DRD4 moderate these relations.

Design

The functional magnetic resonance imaging (fMRI) paradigm investigated blood oxygen level dependent activation in response to imagined intake of palatable foods, unpalatable foods, and glasses of water shown in pictures. DNA was extracted from saliva samples using standard salting-out and solvent precipitation methods.

Participants

Forty-four adolescent female high school students ranging from lean to obese.

Main outcome

Future increases in body mass index (BMI).

Results

Weaker activation of the frontal operculum, lateral orbitofrontal cortex, and striatum in response to

SUBMITTER: Stice E 

PROVIDER: S-EPMC3987805 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature