Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer.

ABSTRACT:

Background

Since volatile and rising cost factors such as energy, raw materials and market competitiveness have a significant impact on the economic efficiency of biotechnological bulk productions, industrial processes need to be steadily improved and optimized. Thereby the current production hosts can undergo various limitations. To overcome those limitations and in addition increase the diversity of available production hosts for future applications, we suggest a Production Strain Blueprinting (PSB) strategy to develop new production systems in a reduced time lapse in contrast to a development from scratch.To demonstrate this approach, Bacillus pumilus has been developed as an alternative expression platform for the production of alkaline enzymes in reference to the established i

SUBMITTER: Kuppers T 

PROVIDER: S-EPMC3987833 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature