Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes.

ABSTRACT:

Purpose

To investigate, in the treatment of uveal melanomas, how tumor control, radiation toxicity, and visual outcomes are affected by the radiation dose at the tumor apex.

Methods and materials

A retrospective review was performed to evaluate patients treated for uveal melanoma with (125)I plaques between 1988 and 2010. Radiation dose is reported as dose to tumor apex and dose to 5 mm. Primary endpoints included time to local failure, distant failure, and death. Secondary endpoints included eye preservation, visual acuity, and radiation-related complications. Univariate and multivariate analyses were performed to determine associations between radiation dose and the endpoint variables.

Results

One hundred ninety patients with sufficient data to evaluate the endpoint

SUBMITTER: Perez BA 

PROVIDER: S-EPMC3988201 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature