Fine mapping of locus Xq25.1-27-2 for a low caries experience phenotype.

ABSTRACT:

Objective

The purpose of this study was to fine map the locus Xq25.1-27-2 in order to identify genetic contributors involved in low caries experience.

Design

Seventy-two families from the Philippines were studied. Caries experience was recorded and genomic DNA extracted from peripheral blood was obtained from all subjects. One hundred and twenty-eight polymorphisms in the locus Xq25.1-27-2, a region that contains 24 genes, were genotyped. Association between caries experience and alleles was tested using the transmission disequilibrium test (TDT). This initial analysis was followed by experiments with DNA samples from 1481 subjects from Pittsburgh, 918 children from Brazil, and 275 children from Turkey in order to follow up the results found in the Filipino families. Chi-squ

SUBMITTER: Kuchler EC 

PROVIDER: S-EPMC3988466 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature