Subjective, physiological, and cognitive responses to intravenous nicotine: effects of sex and menstrual cycle phase.

ABSTRACT: Nicotine dependence is a serious public health concern. Optimal treatment of nicotine dependence will require greater understanding of the mechanisms that contribute to the maintenance of smoking behaviors. A growing literature indicates sex and menstrual phase differences in responses to nicotine. The aim of this study was to assess sex and menstrual phase influences on a broad range of measures of nicotine response including subjective drug effects, cognition, physiological responses, and symptoms of withdrawal, craving, and affect. Using a well-established intravenous nicotine paradigm and biochemical confirmation of overnight abstinence and menstrual cycle phase, analyses were performed to compare sex (age 18-50 years; 115 male and 45 female) and menstrual cycle phase (29 follicular an

SUBMITTER: DeVito EE 

PROVIDER: S-EPMC3988546 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature