The mutation of the rdxA gene in metronidazole-resistant Helicobacter pylori clinical isolates.

ABSTRACT:

Backgrounds

Antibiotic resistance is an increasing problem throughout the developed world, and knowledge about different resistance mechanisms is consequential for efficient treatment of bacterial infections. Although metronidazole has been frequently used in treatment regimens for H. pylori infection, but antibiotic resistance is now a major contributing factor in treatment failure. Nevertheless metronidazole has been greatly used as a critical component of combination therapies for H. pylori infection.

Objective

This study is trying to describe the mutational mechanisms of metronidazole resistance in H. pylori in our clinical isolates in Isfahanian patients, Iran and compare with the findings of previous studies in world.

Materials and methods

MIC values of metronid

SUBMITTER: Mirzaei N 

PROVIDER: S-EPMC3988589 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature