Ontology highlight
ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC3988628 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Liu B B Chen S S Cheng D D Jing W W Helms J A JA
Journal of dental research 20140321 5
Many ciliopathies have clinical features that include tooth malformations but how these defects come about is not clear. Here we show that genetic deletion of the motor protein Kif3a in dental mesenchyme results in an arrest in odontogenesis. Incisors are completely missing, and molars are enlarged in Wnt1(Cre+)Kif3a(fl/fl) embryos. Although amelogenesis and dentinogenesis initiate in the molar tooth bud, both processes terminate prematurely. We demonstrate that loss of Kif3a in dental mesenchym ...[more]